Neurosurgery Department, UF College of Medicine
Research: Clinical Trials
The development of more effective treatments requires that new and innovative therapies be evaluated in patients. The Department of Neurosurgery at the University of Florida provides patients who have brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage, and other disorders with opportunities to participate in clinical trials. Additionally, the Preston A. Wells, Jr. Center for Brain Tumor Therapy, which is co-directed by Dr. William A. Friedman and Dr. Erin M. Dunbar, focuses on basic, translational, and clinical research in the areas of primary and metastatic brain tumors.
Clinical trials are research studies designed to evaluate the safety and effectiveness of new drugs or treatment strategies. The information gained from clinical trials is essential for improving survival, quality of life, and higher standards of care.
Ideas for clinical trials usually come from researchers. After researchers test new therapies or procedures in the laboratory and in animal studies, the experimental treatments with the most promising results are moved into clinical trials. During a trial, more and more information is gained about an experimental treatment, its risks and how well it may or may not work.
Clinical trials are sponsored or funded by a variety of organizations or individuals such as physicians, medical institutions, foundations, voluntary groups, and pharmaceutical companies, in addition to federal agencies such as the National Institutes of Health (NIH), the Department of Defense (DOD), and the Department of Veteran's Affairs (VA). Trials can take place in a variety of locations, such as hospitals, universities, doctors' offices, or community clinics.
Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research.
To learn more about our available clinical trials for brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage and other disorders, please review the clinical trial listings below.
Current Clinical Trials
Brain Tumor |
|
|---|---|
| ACT IV | An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive
Glioblastoma
Contact: , 352-273-9000 |
| RTOG 0913 | Phase I/II Trial of Concurrent RAD001 (Everolimus) With Temozolomide/Radiation Followed by Adjuvant RAD001/Temozolomide in Newly Diagnosed Glioblastoma
Contact: , 352-265-0316 |
| ReACT | A Phase II Study of Rindopepimut/GM-CSF in Patients with Relapsed EGFRvIII-Positive
Glioblastoma.
Contact: , 352-273-9000 |
| 99-2010 | Phase 1, Open-Label, Single-Arm, Clinical and Metabolomics Study of Dichloroacetate (DCA) in Adults With Recurrent Malignant
Gliomas or Brain Metastasis.
Contact: , 352-273-9014 |
| RTOG 0929 | A Randomized Phase I/II Study of ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma. Contact: , 352-265-0316 |
| CTC-01 | Human Glioblastoma Multiforme (GBM) Circulating Tumor Cells (CTCs) as Early, Less Invasive Markers of Progression and Response.
Contact: , 352-273-9000 |
| RTOG 0539 | Phase II Trial of Observation for Low-Risk Meningiomas and of Radiotherapy for Intermediate- and High-Risk Meningiomas. Contact: , 352-273-0316 |
| FCBTR | Establishment of a UF Brain Tumor Tissue Bank: Florida Center for Brain Tumor Research.
Contact: , 352-273-9000 |
Cerebral Aneurysm | |
| PAC | Evaluation of Presidio and Cerecyte Coils in Large and Giant Aneurysms
Contact: , 352-273-9000 |
| PRET | Patients Prone to Recurrence After Endovascular Treatment: A Randomized Trial Comparing Platinum and Hydrogel-Coated Coils. Contact: , 352-273-9000 |
| Gel-the-Nec | Gaining Efficacy Long Term: Hydrosoft, an Emerging, New, Embolic Coil.
Contact: , 352-273-9000 |
| 487-2009 | Biomarkers and Progenitors Following Surgical Intervention for Aneurysm
Contact: , 352-273-9000 |
Stroke | |
| 510-2011 | Genetic Screening and Platelet Inhibition Assay to Identify Patients at Increased Risk for Transient Ischemic Attack or Stroke
Contact: , 352-273-9000 |
Carotid Stenosis | |
| SAPPHIRE | Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy
Contact: , 352-273-9000 |
| 674-2010 | Cognitive Outcome after Carotid Surgery
Contact: , 352-273-9000 |
Subarachnoid Hemorrhage | |
| THIOLA | Phase II Trial of Tiopronin in Aneurysmal Subarachnoid Hemorrhage. Contact: , 352-273-9000 |
Related Links
ClinicalTrials.gov is a registry of federally and privately supported clinical trials conducted in the United States and around the world.
The Florida Cancer Clinical Trial Matching Service offers patients, caregivers and health care professionals up-to-date information about cancer clinical trials in Florida and throughout the United States.
The National Cancer Institute's registry of available clinical trials, clinical trial results, and educational materials.
The Musella Foundation, Clinical Trials and Noteworthy Treatments for Brain Tumors